Associate Professor, Departments of Pediatrics & Child Health, Human Anatomy & Cell Science, Biochemistry & Medical Genetics, and Ophthalmology, University of Manitoba

Director, Advanced Degrees in Medicine Program, Faculty of Medicine (including B. Sc. (Med) and MD/PhD programs)

Scientist, MICH

Senior Investigator, Manitoba Institute of Cell Biology

Director of Neuro-Oncology, CancerCare Manitoba

Scientist, MICH

Senior Investigator, Manitoba Institute of Cell Biology

Director of Neuro-Oncology, CancerCare Manitoba

1997 MA, Neuroscience, University of California
1990 FRCPC, Pediatrics, Royal College of Physicians & Surgeons of Canada
1985 MD, University of Toronto

Developmental Biology (vertebrate)
Developmental Genetics
Forebrain and retinal development
Pancreatic and intestinal development
Enteric nervous system development
Homeobox genes and their transcriptional targets in development
Transgenic mouse models

B. Sc. Medicine students
Agatha Radberger, Medical student, Karolinska Institute
Patrik Radberger, Karolinska Institute
Ceri Richards, University of Manitoba

Graduate students
Mehdi Eshraghi, Masters student, Biochemistry & Medical Genetics (co-supervisor)
Mario Fonseca, Masters student, Human Anatomy & Cell Science
Trung Le, PhD student, Biochemistry & Medical Genetics
Vanessa Pinto, Masters student, Biochemistry & Medical Genetics
Jamie Zagozewski, Masters student, Biochemistry & Medical Genetics
Qi Zhang, PhD student, Human Anatomy & Cell Science

Summer students
Shira Lerner, University of Pennsylvania
Mark Lipson, University of Manitoba (co-supervisor)
Alanna Junaid, University of Winnipeg
Sari Yakubovich, University of Manitoba

Burton T, Eisenstat DD, Gibson SB. Bcl-2 Nineteen kilodalton Interacting Protein (BNIP3) acts as a transcriptional repressor of Apoptosis Inducing Factor (AIF) expression preventing cell death in human malignant gliomas. J Neuroscience 2009; 29(13):4189-4199.

Eisenstat DD. Chromatin immunoprecipitation and the study of gene regulation in the nervous system. In: Binder MD, Hirokawa N, Windhorst U (eds). Encyclopedia of Neuroscience, 4th Ed., Springer, Berlin Heidelberg, 2009; Part 3, p. 710-714.

Wigle JT, Eisenstat DD. Homeobox genes in vertebrate forebrain development and disease. Clinical Genetics 2008; 73(3):1-15.

Wigle JT, Eisenstat DD. Common signaling pathways used during development. Chapter 21. In: Moore KL, Persaud TVN, The Developing Human, 8th Edition, Elsevier Science: Saunders, 2008, p.487-495.

de Melo J, Zhou QP, Zhang Q, Zhang S, Fonseca M, Wigle JT, Eisenstat DD. Dlx2 homeobox gene transcriptional regulation of the TrkB neurotrophin receptor expression during mouse retinal development. Nucleic Acids Research, 2008; 36: 872-884.

Kvakovski A, Schvirtlich M, Zhang Q, Eisenstat DD, Erdélyi F, Baranyi M, Katarova ZD, Szabó G. GAD and Dlx isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens. Developmental Dynamics 2007; 236(12):3532-3544.

Lamparello P, Baybis M, Pollard J, Hol EM, Eisenstat DD, Aronica E, Crino PB. Developmental lineage of cell types in cortical dysplasia with balloon cells. Brain 2007; 130: 2267-76.

Le TN, Du G, Fonseca M, Zhou QP, Wigle JT, Eisenstat DD. Dlx homeobox genes promote cortical interneuron migration from the basal forebrain by direct repression of the semaphorin receptor neuropilin-2. Journal of Biological Chemistry 2007; 282(26): 19071-19081.

Ghashghaei HT, Weber J, Pevny L, Schmid R, Schwab MH, Lloyd KC, Eisenstat DD, Lai C, Anton ES. The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proc Natl Acad Sci USA 2006; 103(6): 1930-1935.

de Melo J, Du G, Fonseca M, Gillespie LA, Turk WJ, Rubenstein JLR, Eisenstat DD. Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina. Development 2005; 132(2):311-322.

Zhou QP, Le TN, Qiu X, Spencer V, de Melo J, Du G, Plews M, Fonseca M, Sun JM, Davie J, Eisenstat DD. Identification of a Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation. Nucleic Acids Research 2004; 32(3): 884-92.