Assistant Professor, Biochemistry and Medical Genetics, University of Manitoba
Canada Research Chair in Genetic Modeling

1997 PhD, University of Leuven, Belgium
1987 Bachelor of Medicine, Shanghai Medical University

My lab focuses on applying mouse transgenic approaches to understand the role of genes during normal development and in pathology.

Sumit Sandhu, PhD student
Pamela Miller, Master student
Nabi Zinnatun, Master student

Zhang, F., Tang, Z., Hou, X., Lennartsson, J., Li, Y., Scotney, P., Lee, C., Arjunan, P., Nagai, N., Kumar, A., Zhu, C., Fariss, R., Dong, L., Tansey, G., Raber, J., Fong, G., Ding, H., et al. Neuroprotective effect of PDGF-C mediated by PDGFR-b and PDGFR-a rescues neurons in both retina and brain. Accepted

Zhang, F., Tang, Z., Hou, X., Lennartsson, J., Li, Y., Koch AW, Scotney, P., Lee, C., Arjunan, P., Dong, L., Kumar, A., Rissanen, TT., Wang, B., Zhu, C., Fariss, R., Dong, L., Tansey, G., Raber, J., Fong, G., Ding, H., Greenberg, D., Becker,K.G., Nash, A., Cao, Y., Watts, RJ., Li, X. VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106(15):6152-7

Jadin, L., Wu, X., Ding, H., Frost, G.I., Onclinx, C., Triggs-Raine, B., Flamion, B. Skeletal and hematological anomalies in HYAL2 deficient mice: a second type of mucopolysassharidosis IX? The FASEBJ, 2008, 22(12):4316-26

Motegi, A., Liaw, H.J., Lee, K.Y., Roest, H.P., Maas, A., Wu, X., Moinova, H., Markowitz, S.D.,
Ding, H., Hoeijmakers, J.H.J., Myung, K. Lysine 63-linked polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc. Natl. Acad. Sci. U.S.A., 2008, 105(34):12411-6

Li, Y., Zhnag, F., Nagai, N., Tan, Z., Zhnag, S., Scotney, P., Lennartsson, J., Zhu, C., Qu, Y., Fang C., Hua, J., Matsuo, O., Fong, G., Ding, H., et al. VEGF-B is an apoptosis inhibitor by suppression of BH3-only protein gene expression via VEGFR-1. The Journal of Clinical Investigation, 2008, 118(3):913-23

Wu, X., Sandhu, S., Ding, H. Establishment of conditional alleles for the gene encoding the regulator of telomere length (Rtel). Genesis, 2007, 45(12):788-792

Wu, X., and Ding, H. Generation of conditional knockout alleles for PDGF-C. Genesis, 2007, 45:653-657

The International Mouse Knockout Consortium . A mouse for all reason. Cell, 2007, 128:9-13

Fredrik, B*., Ding, H*., Wang, T., Hooper, L.V., Koh, G.Y., Nagy, A., Semenkovich, C.F., Gordon, J. The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. U.S.A., 2004, 101(44):15718-15723 (* Both contributed equally as first author)

Ding, H., Wu, X., Bostrom, H., Kim, I., Koh, G.Y., Wong, N., Tsoi, B., O’Rourke, M., Soriano, P., Betsholtz, C., Tam, P.P.L., Nagy, A. A specific requirement of PDGF-C in palate formation and PDGFR-a signaling. Nature Genetics, 2004, 36(10):1111-1116

Ding, H., Schertzer, M., Wu, X., Gersteinsen, M., Kammori, M., Robinson, D., Pourvali, R., Poon, S., Vulto, I., Chavez, E., Tam, P.P.L., Nagy, A., Lansdrop, P.M. Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell, 2004, 117(7): 873-886

Apicelli, A.J., Uhlmann, E.J., Baldwin, R.L., Ding, H., Nagy, A., Guha, A., Gutmann, D.H. Role of the Rap1 GTPase in astrocyte growth regulation. Glia, 2003, 42(3):225-234

Ding, H., Shannon, P., Lau, N., Wu, X., Roncari, L., Baldwin, R.L., Nagy, A., Gutmann, D.H., Guha, A. Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Research, 2003, 63(5):1106-1113

Gutmann, D. H., Huang, Z.Y., Hedrick, N.M., Ding, H., Guha, A., Watson, M.A. Mouse glioma gene expression profiling identifies novel human glioma-associated genes. Ann Neurol, 2002, 51(3):393-405

Ding, H., Wu, X., and Nagy, A. Mice with Cre Recombinase Activatable PDGF-C Expression. Genesis, 2002, 32:181-183

Ding, H., and Guha, A. Mouse Astrocytoma Models: ES Cell Mediated Transgenesis. Journal of Neuro-Oncology, 2001, 53(3): 289-296

Ding, H., Roncari, L., Shannon, P., MacMaster, S., Wu, X., Lau, N., Karaskova,J., Gutmann, D., Squire, J., Nagy, A., Guha, A. Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas. Cancer Research, 2001, 61:3826-3836

Ding, H., Wu, X., Roncari, L., Lau, N., Patrick, S., Nagy, A., Guha, A. Expression and Regulation of Neuropilin-1 in Human Astrocytomas. International Journal of Cancer, 2000, 88(4):584-592

Ding, H., Roncari, L., Wu, X., Patrick, S., Nagy, A., Guha, A. Expression and Hypoxia Regulation of Angiopoietins in Human astrocytomas. Neurooncology, 2001, 1-10

Ding, H., Wu, X., Kim, I., Tam, P.P.L., Koh , G.Y and Nagy, A. The mouse Pdgfc gene: dynamic expression in embryonic tissues during organogenesis. Mechenisms of Development, 2000, 96(2): 209-213

Ding, H., Nagy, A., Gutmann, D.H., Guha, A. A review of astrocytoma models. Neurosurgical Focus, 2000, 8(4): 1-8

Gabriels, J. Beckers, M.C., Ding, H., De Vriese, A., Plaisance, S., van der Maarel, S.M., Padberg, G.M., Frants, R.R., Hewitt, J.E., Collen, D., Belayew, A. Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. Gene, 1999, 236:25-32

Ding, H., Benotmane, A. M., Suske, G., Collen, D., Belayew, A. Functional Interactions between Sp1 or Sp3 and the Helicase-like Transcription Factor mediated Basal Expression from the Human Plasminogen Activator Inhibitor-1 gene. The Journal of Biological Chemistry, 1999, 274(28), 19573-19580

Ding, H., Beckers, M., Plaisance, S., Marynen, P., Collen, D., and Belayew, A. Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3-kb dispersed repeat family. Human Molecular Genetics, 1998, 7(11), 1681-1694

Ding, H., Descheemaeker, K., Marynen, P., Nelles, L., Carvalho, T., Carmo-Fonseca, M., Collen, D., and Belayew, A.: Characterization of a helicase-like transcription factor involved in the expression of the human plasminogen activator inhibitor-1 gene. DNA and Cell Biology. 1996, 15 (6), 429-442