Shyamala Dakshinamurti MD, MSc, FRCPC, FAAP

phone: (204) 789-3233
fax:
Current Positions Held

Associate Professor, Pediatrics, University of Manitoba
Adjunct Professor, Physiology, University of Manitoba
Coordinator of Neonatal Research, University of Manitoba
FRCPC
FAAP

Training, Education & Background

2003 MSc Physiology, University of Manitoba
2001 Neonatology fellowship, University of Manitoba
1998 Pediatrics, University of Chicago
1992 MD, University of Manitoba
1989 BSc University of Winnipeg

Major Research Focus & Interests

The Neonatal Pulmonary Biology lab is a member of the Biology of Breathing group. We are interested in newborn circulatory transition, and the signal transduction pathways regulating vascular smooth muscle function in the pulmonary circuit during perinatal hypoxia. The disease Persistent Pulmonary Hypertension of the Newborn (PPHN) has an incidence of up to 6 per 1000 births, occurring in otherwise healthy infants who undergo deliveries complicated by hypoxia and/or inflammation. Pulmonary hypertension is also a life-threatening complication of chronic hypoxic diseases in the neonate, including bronchopulmonary dysplasia.

Supervised Students

Jena Fediuk
Anurag Singh Sikarwar

Recent Significant Publications

Hypoxic Neonatal Pulmonary Arterial Myocytes Are Sensitized To ROS-Generated 8-Isoprostane. Y. Gong, M. Yi, J. Fediuk, P.P. Lizotte, S. Dakshinamurti. Manuscript in press, Free Radical Biology and Medicine 2009.

Lipid metabolites as regulators of airway smooth muscle function D.L. Clarke, S. Dakshinamurti, A.K. Larsson, J.E. Ward, A. Yamasaki. Pulmonary Pharmacology and Therapeutics 2009 22(5):426-35.

Transumbilical catheter intervention of ductus arteriosus in neonatal swine. A. Divekar, A. Gutsol, S. Dakshinamurti. J Invest Surg. 2007 20(5):313-7

Thromboxane Hypersensitivity in Hypoxic Pulmonary Artery Myocytes: Altered TP Receptor Localization and Kinetics. M. Hinton, A. Gutsol, S. Dakshinamurti. American Journal of Physiology (Lung Cell Mol Physiol) 2007 292(3):L654-63.

Hypoxia Induces Hypersensitivity and Hyperresponsiveness to Thromboxane Receptor Agonist in Neonatal Pulmonary Arterial Myocytes. M. Hinton, L. Mellow, A.J. Halayko, A. Gutsol, S. Dakshinamurti. American Journal of Physiology (Lung Cell Mol Physiol) 2006 290(2):L375-84.

Regulation of Pulmonary Arterial Myosin Phosphatase Activity in Neonatal Circulatory Transition and in Hypoxic Pulmonary Hypertension: A Role For CPI-17. S. Dakshinamurti, L. Mellow, N.L. Stephens. Pediatric Pulmonology 2005 40(5):398-407

Pathophysiologic Mechanisms of Persistent Pulmonary Hypertension of the Newborn. S. Dakshinamurti. Pediatric Pulmonology 2005 39(6):492-503