Professor, Medical Microbiology, University of Manitoba
Associate Dean Research, Faculty of Medicine, University of Manitoba
Adjunct Professor, Physiology, University of Manitoba
Adjunct Professor, Microbiology, Faculty of Science, University of Manitoba
Scientist, MICH

1978 BA, State University College, Geneseo, NY
1982 MA, University of Texas, Austin, TX
1986 PhD, University of Texas, Austin, TX

- to delineate the protein and nucleic acid interactions in nucleoprotein complexes; how these interactions change as a result of, and in turn, are modulated by, conformational transitions that occur during assembly and disassembly; how these processes in virus infections contribute to pathogenesis; and how the host cell Proteome is affected by virus infection.

Alicia Berard, PhD student (co-supervise), apalfi_7@hotmail.com
Anh Tran, PhD student, tranat@shaw.ca
Md. Niaz Rahim, PhD student, niaz_mb@yahoo.com
Lou Wang, MSc student, louloudaxia@yahoo.com.cn
Thais Bernardes, MSc student, thabernardes@gmail.com
Andrea Kroeker, MSc student (co-supervise), grapefruits14@gmail.com
Abdullah Awadh, MSc student, awadhaa@hotmail.com

Xu W, Coombs KM (Dec 2008) Avian reovirus L2 genome segment sequences and predicted structure / function of the encoded RNA-dependent RNA polymerase protein., Virology journal, 5 (1), 153

Douville RN, Su RC, Coombs KM, Simons FE, Hayglass KT (Aug 2008) Reovirus serotypes elicit distinctive patterns of recall immunity in humans., Journal of virology, 82 (15), 7515-23

Tran AT, Xu W, Racine T, Silaghi DA, Coombs KM (Jun 2008) Assignment of avian reovirus temperature-sensitive mutant recombination groups E, F, and G to genome segments., Virology, 375 (2), 504-13

Mendez II, Weiner SG, She YM, Yeager M, Coombs KM (May 2008) Conformational changes accompany activation of reovirus RNA-dependent RNA transcription., Journal of structural biology, 162 (2), 277-89

Hadzisejdic I, Cheng K, Wilkins JA, Ens W, Coombs KM (2006) High-resolution mass spectrometric mapping of reovirus digestion, Rapid Communications in Mass Spectrometry, 20 (3), 438-446

Noad L, Shou J, Coombs KM, Duncan R (2006) Sequences of avian reovirus M1, M2 and M3 genes and predicted structure/function of the encoded mu proteins, Virus Research, 116 (1-2), 45-57

Coombs,KM (2006) Reovirus structure and morphogenesis, Current Topics in Microbiology and Immunology, 309, 117-167

Xu W, Tran AT, Patrick MK, Coombs KM (Aug 2005) Assignment of avian reovirus temperature-sensitive mutant recombination groups B, C, and D to genome segments, Virology, 338 (2), 227-35

Xu W, Patrick MK, Hazelton PR, Coombs KM, Avian Reovirus Temperature-sensitive Mutant TsA12 Has a Lesion in Major Core Protein SigmaA and Is Defective in Assembly., Journal of Virology, 78(20), 11142-51, Oct 2004

Xu W, Patrick MK, Hazelton PR, Coombs KM (Oct 2004) Avian reovirus temperature-sensitive mutant tsA12 has a lesion in major core protein sigmaA and is defective in assembly, Journal of Virology, 78 (20), 11142-51

Robertson CM, Hermann LL, Coombs KM (Oct 2004) Mycophenolic acid inhibits avian reovirus replication, Antiviral Research, 64 (1), 55-61

Yin P, Keirstead ND, Broering TJ, Arnold MM, Parker JSL, Nibert ML, Coombs KM (Sept 2004) Comparisons of the M1 genome segments and encoded mu2 proteins of different reovirus isolates, Virology Journal, 1, 6

Hermann LL, Coombs KM (Jun 2004) Inhibition of reovirus by mycophenolic acid is associated with the M1 genome segment, Journal of Virology, 78 (12), 6171-9

Mendez II, She YM, Ens W, Coombs KM, Digestion pattern of reovirus outer capsid protein sigma3 determined by mass spectrometry, Virology, 311(2), 289-304, July 2003

Swanson MI, She YM, Ens W, Brown EG, Coombs KM, Mammalian reovirus core protein micro 2 initiates at the first start codon and is acetylated, Rapid Communications in Mass Spectrometry : Rcm, 16(24), 2317-24, 2002

Patrick M, Duncan R, Coombs KM, Generation and genetic characterization of avian reovirus temperature-sensitive mutants, Virology, 284(1), 113-22, 2001

Becker MM, Goral MI, Hazelton PR, Baer GS, Rodgers SE, Brown EG, Coombs KM, Dermody TS, Reovirus sigmaNS protein is required for nucleation of viral assembly complexes and formation of viral inclusions, Journal of Virology, 75(3), 1459-75, February 2001

Coombs KM, Stoichiometry of reovirus structural proteins in virus, ISVP, and core particles, Virology, 243(1), 218-28, March 1998

Coombs KM, Temperature-sensitive mutants of reovirus, Current Topics in Microbiology and Immunology, 233 Reovir.i, 69-107, 1998

Yin P, Cheang M, Coombs K M, The M1 gene is associated with differences in the temperature optimum of the transcriptase activity in reovirus core particles., Journal of Virology, 70(2), 1223-7, February 1996