Published by: michadmin on January 21st, 2013
Currently my lab is working on the mechanism involved in the disruption of tight junctions in the intestinal epithelium in graft-versus-host disease.
We have postulated that this event occurs very early in the development of the disease and allows endotoxin to enter the lamina propria. Endotoxin plays a prominent role in driving the cytokine response (IFN-gamma and TNF-alpha). Specifically we are using electrophysiological techniques (in collaboration with Dr. Eric Ghia) to measure early permeability changes before they become apparent at even the ultrastructural level.