Dr. John Gartner

Published by: michadmin on January 21st, 2013

Currently my lab is working on the mechanism involved in the disruption of tight junctions in the intestinal epithelium in graft-versus-host disease.

We have postulated that this event occurs very early in the development of the disease and allows endotoxin to enter the lamina propria. Endotoxin plays a prominent role in driving the cytokine response (IFN-gamma and TNF-alpha). Specifically we are using electrophysiological techniques (in collaboration with Dr. Eric Ghia) to measure early permeability changes before they become apparent at even the ultrastructural level.

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A MICH member is an individual who holds a faculty appointment at a Manitoba university, is involved in child health research, has successfully applied or has been invited to become a MICH member, and enjoys the benefits of affiliation with the Manitoba Institute of Child Health.